Lesson 8 – Concept of Immuno-fertility exam

1. Immune aspects of female fertility

2. Innate Immune Defense in the Male Reproductive System and its
fertility

3. Immune regulatory molecules as modifiers of semen and fertility

4. The molecular tug of war between immunity and fertility

5. The factor that are reported to stimulate male and female
immune response against sperm

Semen antigenicity

Uterine and testicular infection

Impaired pathogen and/or inflammatory response

All of the above

6. Semen is produced along with various immune regulatory
molecules like:

Cytokines

Leukocytes, T cell receptors

Only b)

Both a) and b)

6. H-Y antigen is _________ antigen present only on the sperm cells
of mammalian species

Major histocompatibility antigen

Minor histocompatibility antigen

H-Y antigen regardless of the sex

None of the above

7. Free martin syndrome in cattle is due to the

a) H-Y antigen of female foetus

b) H-Y antigen of Male foetus

c) H-Y antigen regardless of the sex

d) None of the above

8. BTB (Blood testes barrier)

Plays major role in keeping the developing spermatozoa and immune system separate

Prevents the testicular cells expressing foreign antigens from coming into contact with lymphoid tissue

Prevents entry of immune-competent cells from entering the seminiferous tubules

All of the above

9. can be defined as immunoglobins of
the IgG, IgA and/or IgM isotypes that is directed to various
aspects of spermatozoa (head, tail, mid-piece or combination
thereof).

10. The follicular fluid has been found to have high levels of
antibodies and small amount of classes in the
oviduct

11. is the primary organ of secretory immunity in the female
reproductive tract and a true local response can be generated
here.

12. plays a crucial role in primary differentiation of sex
by directing the development of testes and its absence lead to
development of ovaries

13. The permeability of BTB (Blood testes barrier) is times
tighter than peripheral endothelial cells

14. The minor histocompatibility antigen present only on the sperm
cells of mammalian species is .

15. Condition that describes an egg being fertilized by more than one
sperm is called .

16. Antigen found in more than one species, that is capable of
inducing an immune response is called .

17. The major immunoglobulins present in the cervical mucus are .

18. The most attractive target in Oocyte for the regulation of
fertility is .

19. The maternal immune system relies on hormone,
a key regulator of the uterine immune response during
pregnancy

20. Blood-Testis Barrier (BTB):

21. Anti-Sperm Antibodies (ASAs):

22. Associations of ASAs with sperm functional parameters

23. Maternal foetal relationships:

24. . Maternal immunological response to pregnancy:

25. Treatment for immune infertility

26. Immunology and reproduction in male:

27. Immunology and reproduction in the female

28) Antisperm antibodies are less frequent then oocyte antibodies

a) True

b) False

29. Immunologic infertility is probable if more than 50 % sperm are bound
to IgG OR IgA antibodies

a) True

b) False

30. Spermatozoa collected from epididymis more effectively evoke an
immune response than ejaculated spermatozoa.

a) True

b) False

31. Accessory gland secretions increases the antigenicity of the sperm

a) True

b) False

32. Uterine serpines can block lymphocyte proliferation and natural killer
cell mediated abortion

a) True

b) False

33. Freemartin syndrome in cattle is due to the H-Y antigen of the male
foetus

a) True

b) False

34. Cryptorchidism, hypospadias and testicular cancer affect the BloodTestis Barrier integrity

a) True

b) False

35. The cervix is the primary organ of secretory immunity in the female
reproductive tract

a) True

b) False

36. Spermatozoa and seminal plasma don’t express both auto- and alloantigens

a) True

b) False

37. Accessory gland secretions reduce the antigenicity of sperm

a) True

b) False