Lesson 7 – Immune Response exam – Brihha Assessment Platform

1. Which of the following is a large genomic region found in most
vertebrates, playing an important role in immunity?

a) Human Leukocyte Antigens

b) MHC

c) Immunoglobulin

d) Antigen Recognition molecules

2. Which of the following is NOT true when comparing primary immune
response to subsequent immune response

a) Primary response takes 5 to 10 days

b) Primary response has high affinity for Antigen

c) Secondary response takes 1 to 3 days

d) Primary response has IgM as major Ab.

3. For the body to develop immunologic tolerance, production of
_________ must be prevented.

a) Antibodies

b) Auto antibodies

c) Antigens

d) Lymphocytes

4. Which of the following option is the mechanism for induction of
immune tolerance?

a) Clonal Anergy

b) Peripheral Anergy

c) Central Anergy

d) All of the above

5. An example of a privileged immunological site is the:

a) Bone marrow

b) Testis

c) Skin

d) Lung

6. Several cytokines may have the same effect on the cells they bind.
This is an example of

a) A cascade

b) Synergy

c) Pleiotropism

d) Redundancy

7. Interferons

a) Activate B-cells to make virus specific Abs

b) Block virus infection of host cells.

c) Viral proteins interfere with cytotoxic T-cells

d) Inhibit virus replication

8. Complement is involved in all of the following except

a) Increased presence of serum proteins in the infected tissues.

b) Sensitization of T-cells to antigen

c) Lysis of bacteria in the absence of antibodies.

d) Opsonization of microorganisms

9. The signal transduction molecules associated with TCR are

a) CD1

b) CD8

c) CD3

d) CD4

10. Th1 cells secrete cytokines which

a) Activate macrophages

b) Inhibit macrophage secretion

c) Increase susceptibility to allergic reaction

d) B-cells to secrete neutralizing Ab

11. Original antigenic sin causes

a) Suppress the activation of naïve cells

b) Stimulate memory cells than naïve cells

c) An autoimmune response

d) Responses to influenza virus

12. Type II hypersensitivities involve

a) Cytotoxic T-cell mediated lysis of antibody coated cells

b) IgE-mediated degranulation of mast cells

c) Complement mediated lysis of antibody coated cells

d) Chemotaxis of eosinophil

13. A Type III hypersensitivity reaction is mediated by

a) Autoimmune reactions to self tissue antigens.

b) Antibody reacting with membrane antigen epitopes.

c) Cell-mediated branch of the immune system.

d) Immune complexes deposited in the blood vessel, kidneys and joints.

14. Type IV hypersensitivity (DTH)

a) Mediated by memory macrophages

b) Passively transferred with CD4 T-cells

c) Occurs 1-2 weeks after antigen exposure

d) IgG antibodies which are produced late in an immune response

15. A common feature of all hypersensitivities is

a) Activation of CTL and Th2 cells

b) Antibody synthesis

c) Inflammation

d) All of the above

16. Induction of autoimmunity usually involves

a) Activation of antigen-specific T cells

b) Recruitment of antigenspecific dendritic cells to the lymph nodes

c) Anergy of antigen-specific B cells

d) Development of autoimmune disease with certain HLA alleles

17. Super antigens

a) Avoid immune elimination by only activating T-cells.

b) Recruitment of antigenspecific dendritic cells to the lymph nodes

c) Induce a very strong (super) immune response against the pathogens that produce them.

d) Induce CD4 T-cells to produce cytokines to inhibit immune response

18. Primary and secondary humoral immune responses do NOT differ
in their

a) Antibody affinities

b) Peak antibody titers and kinetics

c) Effector mechanisms

d) Ratio of IgM:IgG

19. Successful immune responses to bacterial toxins depend on the
production of

a) Armed effector CTL

b) Opsonizing antibodies

c) Oxidative burst

d) Neutralizing antibodies

20. Cells receive a death signal through

a) Fas

b) STAT ligand

c) Fas ligand

d) Bcl-2 receptor

21. Cytokines may exhibit action, signaling the cells that
produce them.

22. Complements participate in both and immune
responses

23. Complement system acts through , and
pathways.

24. The first component of the classic pathway is .

25. The complement binds to immunoglobulin molecule at of
the domain.

26. complement component is called as classic C3 convertase.

27. The most important complement component is .

28. The half life of the alternative pathway C3 convertase is enhanced by
protein.

29. The alternative pathway is controlled by factors and .

30. The larger triggers the assembly of a
which can result in the lysis of certain pathogens.

31. Type I hypersensitivity reactions involve antibody
against soluble antigen triggering mast cell degranulation.

32. Type II hypersensitivity reactions involve and
antibodies directed against cellular antigens, leading to cell
damage mediated by other immune system effectors.

33. Type III hypersensitivity reactions involve the interactions of ,
and occasionally, antibodies with antigen to form
immune complexes.

34. Type IV hypersensitivity reactions are reactions that
can involve tissue damage mediated by activated macrophages and
cytotoxic T cells.

35. Cytokines exhibit the attributes of , ,
and .

36. Delayed-type hypersensitivity is initiated by of cell
mediated branch.

37. Antibody dependent cell mediated cytotoxicity (ADCC) involves
reactions

38. is the primary mechanism by which immune
tolerance of T- lymphocytes is achieved.

39. is the state of inactivation in which the lymphocytes
remain alive, but are unable to respond to antigen.

40. Clonal selection

41. Cytokines

42. Complement system

43. Regulatory T-cells (Tregs)

44. C3 convertase

45. Hypersensitivity

46. Interleukin

47. Tumor necrosis factor (TNF)

48. Anergy

49. Lectin pathway

50. Explain in detail about the various pathways of complement system
and its role in immunity.

51. Enumerate specific allergic conditions of Type I hypersensitivity and
explain in detail about other types of hypersensitivity and sequel.

52. Most of the antibodies in a primary immune response are of the IgM isotype.

A) True

B)False

53. In alternative pathway do always require Ag-Ab complex for the initiation of complement pathway.

A) True

B)False

54. Individuals with unusually high level of IgE class antibodies are called as atopic individuals.

A) True

B)False

55. IFN ? from Th 1 cells will not inhibit IL4 production by Th2 cells.

A) True

B)False

56. Leukotriene, histamine and C5a are eosinophil chemotactic factors.

A) True

B)False

57. Cytokine IL4 is not playing any role in type I hypersensitivity.

A) True

B)False

58. Erythroblastosis fetalis is due to type II hypersensitivity reaction.

A) True

B)False

59. The lesions in immune complex-induced glomerulonephritis are dependent on erythrocytes and complement.

A) True

B)False

60. Type II hypersensitivity requires immune complex formation.

A) True

B)False

61. TH1 and Tc cells are involved in type IV hypersensitivity reaction. Type IV hypersensitivity reactions take 48-72 h to develop.

A) True

B)False

62. Macrophages are involved in type IV hypersensitivity reaction.

A) True

B)False

63. Delayed type hypersensitivity test can be done to diagnose leprosy and coccidiomycosis.

A) True

B)False

64. Hypersensitivity type I, II and IV reactions may develop as a result of vaccination of animals in the field conditions.

A) True

B)False

65. Contact dermatitis is mediated by IgE.

A) True

B)False

66. IgG is much less active than IgM in activating complement.

A) True

B)False

67. C3a & C5a are called anaphylatoxins.

A) True

B)False

68. C3b is not a major opsonin of the complement system.

A) True

B)False

69. The complement deficiencies will interfere with effective solubilization and clearance of immune complexes.

A) True

B)False

70. Activation of complement components will not facilitate opsonization.

A) True

B)False

71. The proteins of complement system mainly synthesized by liver hepatocytes.

A) True

B)False

72. Congenital deficiencies of complement components increase susceptibility to infection.

A) True

B)False

73. Explain in detail about the various pathways of complement system and
its role in immunity.

74. Enumerate specific allergic conditions of Type I hypersensitivity and
explain in detail about varies factor involved in initiation of Type I
hypersensitivity and squeal