Lesson 5 – Types of Immunoglobulin exam – Brihha Assessment Platform

1.The order of percent of total immunoglobulin in serum is,

a) IgA, IgG, IgM, IgE, IgD

b) IgG, IgA, IgM, IgE, IgD

c) IgM, IgA, IgG, IgD, IgE

d) IgG, IgA, IgM, IgD, IgE

2. Which of the following antibody is prominent antigen receptor
expressed on B Cells?

a) IgA,

b) IgG

c) IgM

d) IgE

3. Which of the following antibody is an important host defense against
encapsulated bacteria?

a) IgG2

b) IgG1

c) IgG3

d) IgG4

4.Complement fixation is one of the most important host defense against
infections and the complement is activated by

a) IgM only

b) IgG only

c) both IgM and IgG

d) All five classes of antibodies activate complements

5. Which of the following immunoglobulin has the highest avidity of the
immunoglobulins?
,

a) IgA

b) IgM

c) IgG

d) IgE

6. Which of the following animals lack heavy chain in their antibodies?

a) Camel

b) Mice

c) Pigeon

d) Dog

7. Using only random VDJ recombination, from 40 V, 30 D and 6 J gene
segments, the number of possible variable regions of an antigen
receptor molecule would be:

a) 36

b) 76

c) 70

d) 7200

8.The molecules mediating signal transduction following antigen binding
to cell surface immunoglobulin on a B-cell are called:

a) Ig Fc

b) MHC

c) Ig-alpha and Ig-beta

d) CD4

9. Genes for immunoglobulins are unlike other human genes in that

a) Each polypeptide chain is encoded by several exons.

b) Ig genes are composed of introns and exons

c) Somatic recombination occurs before mRNA is transcribed

d) both b and c are true

10. Pseudogenes are DNA sequences which look very similar to functional
genes except for the presence of a(n)

a) Intron

b) Stop codon

c) Leader sequence

d) Promoter codon

11. Each B-cell productively rearranges a single H and L chain allele and it
exhibits

a) Allelic exclusion

b) Affinity

c) Antibody diversity

d) Cross reactivity

12. Somatic recombination occurs

a) in the mature B cell following antigen contact

b) in the bone marrow stem cell.

c) in the progenitor cell as it is becoming a B-cell.

d) in the plasma cell after antigen contact.

13. Junctional diversity affects primarily the amino acid sequence in

a) all CDR equally

b) CDR1.

c) CDR2

d) CDR3

14. Isotype switching

a) Changes the leader sequence exon so the antibody is secreted.

b) Improves the antigen binding specificity of an Ig molecule.

c) Increases the affinity of antibodies in a process called affinity maturation.

d) Increases the functional diversity of Ig molecules.

15. Isotype switching is always productive because

a) Recombination between switch sites occurs in introns so it cannot introduce stop codons into coding regions.

b) No DNA is deleted from the chromosome in isotype switching.

c) Isotype switching does not involve recombination of DNA gene segments.

d) No effector diversity results from isotype switching.

16. Alpha heavy chain is present in

a) IgD

b) IgG

c) IgA

d) IgE

17.The class-specific antigenic determinants of immunoglobulins are
associated with the

a) Light chain

b) Heavy chain

c) J chain

d) Secretory component

18. IgA can be secreted from the body because it

a) Binds poly-Ig receptor on mucosal epithelial cells.

b) Has a specialized H chain called secretory chain.

c) Has a special secretory idiotype.

d) Small enough to pass between mucosal epithelial cells and leave the body

19. Genes for immunoglobulins are unlike other human genes in that

a) Genes are composed of introns and exons.

b) Gene segments must be spliced together to make each unique Ab molecule.

c) Several exons encode each antibody molecule.

d) DNA for antibody molecules is inherited from only one parent

20. Primary mRNA for H-chain encodes

a) One VH, one DH and multiple JH segments.

b) One VH, one DH, and one JH segment

c) Multiple VH, one DH, and one JH segments.

d) Multiple VH, one DH, and multiple JH segments

21. Most heavy chains have constant domains (CH1, CH2, and
CH3), but those of and antibodies have four constant
domains.

22. IgG and IgM have and antigenic determinants
respectively in heavy chain.

23. immunoglobulin is responsible for local immunity.

24. is immunoglobulin isotype found in highest concentration in
serum.

25. and immunoglobulins with the membrane bound
receptors on B cells.

26. immunoglobulin is present in saliva.

27. immunoglobulin is transported through placenta.

28. is first immunoglobulin in any immune response.

29. Major immunoglobulins present in secondary immune response
are .

30. Immunoglobulin is involved in immediate hypersensitivity
reaction and is involved in immune complex disease.

31. Immunoglobulin domains of variable regions have
within the β-sheet structure.

32. Idiotype of an antibody is determined by .

33. Hinge region is not present in %BLANK% antibody.

IgM

34. ‘J’ chain is present in and immunoglobulin structure.

35. Hinge region is absent in and immunoglobulins.

36. Clonal selection theory was proposed by .

37.VDJ recombination

38. N-nucleotides

39. 12/23 rule

40. Junctional diversity

41. RAG1 and RAG2

42. Complementary Determining Region (CDR)

43. Somatic hypermutation

44. Class switch recombination

45. Allelic exclusion

46. What do you mean by diversity of antibody? Briefly explain mechanism
of it.

47. Enumerate Major classes of immunoglobulins and subclasses of bovine
immunoglobulin, describe in detail about the structure of IgG.

48. Differentiate between the various classes of immunoglobulins with
their structure, functions and properties.

49. Granulocytes produce antibodies.

A.)True

B.)False

50. Antibodies are Y-shaped molecules formed by four protein chains which have similar length.

A.)True

B.)False

51. Antibodies binding domain (ABD) are the specific sites on the antigens which can bind to antibodies.

A.)True

B.)False

52. There can be multiple epitopes on antigen.

A.)True

B.)False

53. IgM molecule is a dimmer.

A.)True

B.)False

54. IgD has gamma antigenic determinant in heavy chain.

A.)True

B.)False

55. IgA occurs more in secretions.

A.)True

B.)False

56. The major class of Ig synthesized in a secondary immune response is IgG.

A.)True

B.)False

57. IgM is made up of five identical subunits.

A.)True

B.)False

58.IgG is the major immunoglobulin in colostrum, saliva and tears.

A.)True

B.)False

59.IgA has gamma antigenic determinant in heavy chain.

A.)True

B.)False

60.H chain joins two monomers in IgA.

A.)True

B.)False

61.IgG has delta antigenic determinant in heavy chain.

A.)True

B.)False

62.Hinge region is absent in IgM.

A.)True

B.)False

63.The major class of immunoglobulin synthesized in a secondary immune response is IgG.

A.)True

B.)False

64.Babies can acquire IgE-mediated allergies by passive transfer of maternal antibody.

A.)True

B.)False

65. Briefly mention the different theories of antibody formation.

66. What do you mean by diversity of antibody? Briefly explain mechanism
of it.

67. Differentiate between the various classes of immunoglobulins with
their structure, functions and properties.