Lesson 1 Mutation exam – Brihha Assessment Platform

1. Describe the types of mutations that can occur in a gene and their
effect, on the protein that is produced when the gene is expressed.

2. Describe how a mutation might occur by distinguishing between
spontaneous and induced mutations.

3. Describe the method of detection of mutation in laboratory

4. Enlist the mutation process affecting coat colour of animal’s suitable
examples.

5. Notch wing mutation in Drosophila is as a result of

Deletion

Duplication

Inversion

Translocation

6. Sickle cell anemia is due to point mutation, in which

Glu. Is replaced by Val.

Val. is replaced by glu.

His. Is replaced by Val

Val. is replaced by his.

7. The mutational mechanism in β-thalassemia consists of

a deletion

a duplication

an insertion

. a point mutation

8. Which of the following can give rise to new genes?

Duplication

Unequal crossing over

Mutation

All of the above

9. A point mutation that changes codon to represent a different amino
acid is called

Nonsense mutation

Missense mutation

Silent mutation

All of the above

10. Mutation to a particular gene is most effective

in increasing its frequency when the mutant gene is rare

in decreasing its frequency when the mutant gene is rare

in increasing its frequency when the mutant gene is common

in decreasing its frequency when the mutant gene is rare

11. At equilibrium between forward and reverse mutation the frequency
of gene is related with

mutation rate

initial gene frequency

initial genotype frequency

. None of the above

12. 5-Bromo Uracil is a

Base analogue

Alkylating agent

Deaminating agent

Hydroxylating agent

13. CIB technique is useful for detection of mutation in

Drosophilla

Monkey

Rabbit

Mouse

14. Mutation was discovered

Hugo de Vries

Morgan

Wright

None of the above

15. X linked mutation follows pattern of inheritance.

16. CIB system is useful for detection of

17. Acridine dyes can cause mutation

18. Alkylating agents can cause transfer of groups

19. Oxidative deamination is caused by .

20. When purine is replaced by pyrimidine or vice versa it is called .

21. Euploidy is a type of chromosomal aberration.

22. individual has one chromosome less than the normal
number of chromosomes.

23. Pseudo dominance is due to mutation.

24. Mutation occurs more frequently at certain regions of genes called
as

25. Germline mutations may be transferred to progeny.

True

False

26. Non-ionizing radiation can also cause mutation

True

False

27. Ethidium bromide is an intercalating agent.

True

False

28. Keto-thymine can form enol-thumine after tautomeric shift.

True

False

29. Recessive mutation is usually lethal.

True

False

30. Change of amino acid occurs due to mis-sense mutation.

True

False

31. PNA clamping can be used for mutation assay.

True

False

32. Mutagenic nature of X-rays was discovered by Muller.

True

False

33. The diploid organisms which have one extra chromosome are called
trisomies.

True

False

34. Temperature can also increase the mutation rate.

True

False