Lesson 7 – Interleukins exam – Brihha Assessment Platform

1. Interleukins, interferons, transforming growth factor β, and TNF-α:
Receptors, functions and roles in diseases

2. Clinical Applications of Cytokines (Cytokine therapy).

3. Cytokines in Autoimmunity: Role in Induction, Regulation, and
Treatment.

4. The characteristic properties of cytokines are

Synergy and antagonism

Cascade induction and amplification

Pleiotrophy and redundancy

All of the above

5. Interleukin-1 is an inflammatory cytokine that has the following
function except:

Inflammation

Leukocyte adhesion

Production of acute phase reactant protein

All of the above

6. Which of the following class of cytokine receptors utilize G-protein
coupled receptor for its downstream function?

Interferon receptor

Hematopoietin receptor

Chemokines receptor

None of the above

7. Interferon type I mediate the early innate immune response to viral.
Which of the following viral antigens activates production of Type I
interferon?

Double-stranded DNA

Capsid protein

Double-stranded RNA

None of the above

8. Which of the following cytokine antagonizes the function of IL-12 and
absence of specific cytokine in mice develops inflammatory bowel
disease?

IL-1

IL-10

IFN-gamma

9. Which of the following cytokine is used for the treatment of chronic
granulomatous disease?

INF-gamma

INF-alpha

INF-beta

TNF

10. Which of the following cytokine is used for the treatment of viral
hepatitis and multiple sclerosis?

INF-alpha

INF-gamma

INF-beta

TNF

11. Which of the following interleukin is responsible for T cell expansion
after antigen recognition?

IL-5

IL-1

IL-2

IL-4

12. Tumor necrosis factor (TNF) is an endogenous pyrogen that induces
fever. Which of the following statement is true regarding TNF except

TNF induces the synthesis of prostaglandins

TNF induces IL-1 production for induction of fever

TNF level is lower in septic shock

TNF induces production acute phase proteins

13. Cytokines always act:

In an autocrine fashion

Antagonistically with other cytokines

Synergistically with other cytokines

By binding to specific receptors

14. Which of the following cytokines stimulate the production of IgA that is
required for mucosal immunity?

Tumor Necrosis Factor

Transforming growth factor-beta

Interferon-gamma

All of the above

15. Cytokines recognize and engage with their receptors for biological
action. Which of the following is the correct sequence of high-affinity
to low-affinity interactions?

Cytokine > Antibody > MHC

MHC> Antibody > Cytokine

Antibody> MHC > Cytokine

None of the above

16. Cytokines regulate the intensity and duration of the immune response
by activating or downregulating both innate and adaptive immune
response. The mode of action of the cytokine is the following except

Autocrine

Endocrine

Paracrine

Cell-autonomous

17. Interleukin 12 is a key inducer of the cell-mediated immunity in
response to infection by intracellular pathogens. Interleukins activate
cell-mediated immune response by increasing synthesis of the
following cytokines

Interferon β (beta)

Interleukin

Interferon γ (gamma)

TNF

18. Chemokines are the structurally homologous cytokines family that
regulate lymphocyte migration. Which of the following is an incorrect
statement regarding the cytokines?

Chemokines are suppressed by microbes, TNF and IL-1

Chemokines consist of characteristic N-terminal cysteine residues

Chemokines are produced by endothelial cells, epithelial cells, and fibroblasts

Chemokines bind to the heparan sulfate on the endothelial tissue that enables recruitment and trapping of cells into infection sites

19. Cytokines:

Have glycosyl phosphatidylinositol (GPI) anchors

Are usually around 150–200 kDa

Generally act at long range

Can be pleiotropic

20. Cytokines produced by monocytes or macrophages are called as .

21. The majority of interleukins are synthesized by .

22. The main function of chemokines is to direct immune cells to the site
of inflammation via .

23. Functions of Interleukins

24. Clinical Significance of Interleukins:

25. Discuss the common families of interleukins

26. The term interleukin was coined by Dr.Vern Paetkau and approved by
IUIS

True

False

27. Cytokines can be pleiotropic

True

False

28. The majority of interleukins are synthesized by helper CD4 Blymphocytes

True

False

28. The main function of lymphokines is to direct immune cells to the site of
inflammation via macrophages

True

False

29. Cytokines always act by binding to all types of receptors

True

False