Lesson 4 – Major Histocompatability Complex (MHC) exam

Welcome to your Lesson 4 - Major Histocompatability Complex (MHC) exam

1. Analysis of Major Histocompatibility Complex (MHC).
2. Structure, function and genetics of the major histocompatibility
complex (MHC).
3. Physical assignment of the bovine MHC class IIa and IIb genes.
4. The area of contact between membranes of a T cell and an antigenpresenting cell where a clustering of protein–protein interactions
occur is called a(n)
5. Which of the following cell types is not considered a professional
antigen-presenting cell?
6. The CD4 protein of T helper cells binds and stabilizes the MHC class
II/peptide structure. The subunit that interacts with CD4 cell surface
protein is
7. The antigen recognition by T cell depends on the presence of specific
MHC molecules in the antigen-presenting cell which is
8. The MHC proteins are highly polymorphic. The following factors
contribute to the polymorphism, except
9. Major Histocompatibility Complex (MHC-I) molecules are the cell
surface proteins activates T cells and mediate effector T-cell function.
Which of the following class of MHC molecules activate cytotoxic T
cells?
10. Major Histocompatibility Complex is a tight cluster of linked
11. Which of the following polypeptide is important for the expression of
MHC I on the cell membrane?
12. Name the class of MHC which is recognized by CD4 TH cell.
13. MHC class I is a cell surface molecule present on
14. MHC class II is a cell surface molecule present on
15. Which of the following is not produced by cytotoxic T cells?
16. Which type of antigen-presenting molecule is found only on
macrophages, dendritic cells, and B cells?
17. MHC class II molecules are made up of two chains called _______,
whose function is to bind peptides and present them to _______ T
cells:
18. The   is a chromosomal
region consisting of a group of closely linked loci of immunological
importance controlling many related immunological functions
19. Sheep MHC system is called as
20. MHC is located on the short arm of in human and
chromosome in cattle
21. Class I MHC molecules contain two separate polypeptide chains
namely the and the .
22. Class II MHC molecules bind peptides derived from  that are internalized by phagocytosis or endocytosis
23.  of thymocytes is necessary to produce a T-cell
repertoire capable of interacting with self-MHC molecules.
24. Class II MHC molecules bind peptides derived from exogenous
antigens that are internalized by .
25. MHC II molecules are made up of two subunits (α and β) of
approximately equal size, whereas MHC I molecules consist of a
larger α subunit and a smaller subunit called .
26. MHC Class I Molecule:
27. MHC Class II Molecule:
28. Application of MHC in Bovines
29. FUNCTIONS OF MHC
30. A peptide-binding groove is formed between α1 and α2 helices with
beta-pleated sheet as its floor
31. Class I MHC molecules contain two separate polypeptide chains
namely the heavier alpha chain and the lighter beta chain
32. The MHC genes of mammals are organized into four classes
33. Class I MHC molecules bind peptides derived from exogenous
antigens that are internalized by phagocytosis or endocytosis
34. Macrophages comes under Non-professional antigen-presenting
cells
35. Class III MHC antigens are associated with proteins in serum and
other body fluids and have no role in graft rejection
36. Class II molecules acted as restriction elements for CD4+ helper
37. The Major Histocompatibility Complex (MHC) is a chromosomal
region consisting of a group of not closely linked loci of
immunological importance controlling many un related
immunological functions
38. Goat MHC system is called as Ovine Lymphocyte Antigens (OLA).
39. MHC is located on the short arm of chromosome 23 in small
ruminant
40. Class II MHC molecules contain two separate polypeptide chains
namely the heavier alpha chain and the lighter beta chain
41. Class II MHC molecules bind peptides derived from exogenous
antigens that are internalized by phagocytosis or endocytosis