Lesson 2 – Organs and cells of immune system exam

1. Which lymphoid organ is the site of erythrocyte, leukocyte and
lymphocyte production?

a) Adenoid

b) Lymph nodes

c) Spleen

d) Thymus

2. Where are plasma cells found in a lymph node?

a) In the lymph sinuses

b) In the medullary cords

c) In the cortex

d) In the capsule

3. Which one is the major lymphoid organ thatstimulate T-lymphocytes
to become immunocompetent?

a) Thymus

b) Spleen

c) Peyers patches

d) Tonsils

4. The lymphocyte antigen receptor repertoire is mostly generated

a) By cutting and splicing V,D,J or D gene segments

b) Mutation of the TCR regions

c) Immediately after vaccination

d) Exposure to antigen

5. Antibody binds to mast cells and basophils to invoke inflammation

a) IgM

b) IgA

c) IgG

d) IgE

6. T-lymphocytes

a) Can ingest pathogens and kill them

b) Can recirculate through blood and lymphoid organs

c) Are short lived

d) Are stored in bone marrow

7. Which lymphoid organ that is active in younger ages, but decreases
in size and gets importance in adulthood?

a) Adenoid

b) Lymph nodes

c) Spleen

d) Thymus

8. There are molecules on the surface of cells that provide identity for
the cells. The body either recognizes these cells as “self” or “nonself.” Which of the follow are molecules that are NOT involved in cell
identity?

a) Antigens

b) Antibody

c) MHC complex

d) Complement

9. Which of the following is/are primary lymphoid organs?

a) Thymus

b) Spleen

c) Bone marrow

d) Both A and C

10. Which of the following organ in mammals is the equivalent for
bursa of Fabricius in birds?

a) Spleen

b) Liver

c) Thymus

d) Bone marrow

11. APC's present and process bacterial antigen by

a) Cytolytic pathway

b) Endogenous pathway

c) Both

d) None of the above

12. The peri-arteriolar lymphoid sheath is

a) Thymus-dependent region of the spleen

b) Thymus-dependent region of the lymph nodes

c) Thymus-independent region of the spleen

d) Thymus-independent region of the lymph nodes

13. B-cells do not express

a)C3 receptors

b)Class II molecules

c) Class I molecules

d)CD4 molecules

14. Cytotoxic T-cells are identified by antibodies against

a) CD8

b) CD4

c) CD3

d) CD11

15. Which of the following is/are true concerning macrophages?

a) they secrete monokines

b) they can adhere to glass or plastic

c) they have associated enzyme markers

d) all of these

16. Which of the following is/are not true concerning NK cells?

a) they have Fc receptors

b) their activity is MHC restricted

c) they are found in beige mice

d) they are spontaneously cytotoxic

17. If all of an animal's immune cells are destroyed, which of the following cells may reconstitute the entire immune system?

a) Thymocytes

b) Bone marrow stem cells

c) Lymph node cells

d) T-lymphocytes

18. In which of the following organs does antigen-dependent proliferation of different lymphocytes take place?

a) Spleen

b) Lymph nodes

c) A and B are correct

d) Neither ‘a’ nor ‘b’ is correct

19. In which of the following organs does antigen-independent
maturation of different lymphocytes take place?

a) Thymus

b) Lymph nodes

c) Bone marrow

d) ‘a’ and ‘c’ are correct

20. Lymphocyte recirculation

a) Activate cytokine to promote antigen presentation to T-cells.

b) Allows B cells to go to the site of infection to produce antibody.

c) Circulates lymphokines efficiently throughout the body.

d) Occurs for both naïve and effector lymphocytes

21. Macrophages are attracted to the site of infection by all of the
following EXCEPT

a) Bacterial peptides.

b) Chemokines

c) C5a

d) IL-8

22. T-cells are activated to armed effector cells when they encounter
antigen on

a) Blood-borne pathogens.

b) Bone marrow stromal cells.

c) Professional APC

d) Virus-infected tissues

23. Membrane events required for Th activation include all of the
following EXCEPT binding of T-cell

a) CD4 to APC Class II MHC.

b) CTLA-4 to APC B7.

c) High affinity IL-2 receptor to IL-2.

d) LFA-1 to APC ICAM

24.T-cell which binds antigen without undergoing a co-stimulatory
signal from and

a) Becomes inactivated.

b) Can become a helper cell but not a killer cell.

c) Can get a co-stimulatory signal from a different APC

d) Dies

25. Dendritic cells are the best APCs for activating

a)CTL

b) Helper T-cells

c) Naïve T-cells

d) Th1 cells

26. B-cells differ from the other professional APC because B cells

a) Activate T cells in the secondary lymphoid organs.

b) Present exogenous antigen to T cells on Class II MHC.

c) Present only peptides from antigens they bind with their membrane Ig.

d) Use B7 as their co-stimulatory molecule.

27. Armed effector T cells differ from naïve T-cells in that effector
cells

a) Are not antigen-specific.

b) Do not need to bind co-stimulatory molecules.

c) Do not need to bind peptide plus MHC.

d) Do not use CAMs to bind other cells.

28.The effector molecules of cytotoxic T cells do NOT include

a) Fas

b) Granzymes

c) IFN

d) Perforin

29. CTL binding and destruction of target cells depends on

a) Co-stimulatory signal from the target cell.

b) Antigen presentation on the surface of the target cell.

c) Lack of a negative signal from MHC to prevent cytotoxicity.

d) Presence of virus proteins in the membrane of the target cell.

30. T-independent antigens do NOT

a) Bind to BCR.

b) Get presented on MHC Class II.

c) Have repeating epitopes.

d) Induce B cell proliferation.

31.Before a B-cell can receive T-cell help, the B-cell must

a) Express membrane B7.

b) Express membrane CD40L.

c) Express membrane IFN receptors.

d) Process and present peptide on Class II MHC.

32. In order for T cells to provide help to B cells, T cell and B cell
epitopes must be

a) Covalently linked

b) Identical

c) Non-identical

d) Peptides

33.B-cell isotype switching is important for

a) Increasing the avidity of the antibody.

b) Providing antibodies of many different antigen specificities.

c) Providing antibodies which can perform different effector functions.

d) Signaling the B-cells to become activated by follicular dendritic cells

34.Different Ig isotypes are found in different body locations because
they

a) Are secreted in different tissues.

b) Bind to different FcR that allow them to cross tissue barriers.

c) Have different addressins.

d) Have different affinities for antigen.Your new question!

35.Mast cells release their granule contents to stimulate
inflammation in response to

a) Antigen binding to IgE on mast cell FcR.

b) Antigen binding to IgG on mast cell FcR.

c) Antigen binding to mast cell antigen receptors.

d) Antigen binding to mast cell FcR.Your new question!

36.Armed effector CTL find and kill their target cells in

a) Draining lymph nodes.

b) Site of pathogen entry into the body.

c) Spleen.

d) Whatever tissues are infected.

37.Naïve lymphocytes enter the lymph nodes

a) Any time they pass by the lymph node HEV.

b) Any time inflammatory chemokines signal them to go to the lymph nodes.

c) Only during infection.

d) Only when their specific antigen is NOT present in the tissues.

38. Immune memory is provided by persisting

a) Antibody molecules.

b) Effector CTL.

c) Memory cells that can be activated by antigen to become effectors.

d) Plasma cells

39. The function of the M-cells is to

a) Induce apoptosis in food antigens.

b) Kill infected enterocytes.

c) Migrate to the Peyer's Patches and present antigen to T cells.

d) Phagocytose or endocytose antigen.

40.Plasma cells activated in the gut-associated lymphoid tissue
secrete IgA in the

a) Bone marrow.

b) Lamina propria lymphoid tissues.

c) Mucosa of gut, lungs, and genital tracts.

d) Peyer's Patches.

41. The paracortical area of a lymph node mainly comprises of

42. express the surface protein CD4 which binds to class II MHC
molecules .

43. Thymosin is a hormone that will cause to maturate.

44. Lymphoid organs can be classified into two types namely
and

45. and are the most important secondary lymphoid organsYour new question!

46. Directed migration of neutrophils is called

47. are the phagocytic cells that arrive first to the site of
inflammation.

48. Lymphocytes can be broadly subdivided on the basis of function and cell
membrane components into three population namely ,
and .

49. Antigen presenting cells are , and .

50. are the macrophages found in the liver

51. are the dentritic cells found in the epidermis and
mucous membrane

52. B-cells when it contact with the antigen, it will differentiates into
and

53. Null cells are cells.

54. A primary lymphoid organ located in the thoracic cavity is .

55. is responsible for maturation of T-Lymphocytes

56. Anamnestic response is due to the presence of .

57. The equivalent structure of Bursa of Fabricius in mammal is

58. is the largest lymphoid organ.

59. is the antibody secreting cell.

60. cells constitute first line of defence.

61. Tissue macrophages found in kidney are

62. are very potent antigen presenting cells.

63. Two types of mast cells are and .

64. are the key cells of the immune response

65. The function of secondary lymphoid organ is .

66. Antibody-dependent cellular cytotoxicity (ADCC)

67. Antigen-presenting cells

68. Co-stimulators

69. Effector cell

70. Helper T-cells

71. Positive selection

72. Negative selection

73. Cytotoxic T-cell

74. Dendritic cells

75. Mast cells

76. Name the three morphologic areas of the lymph node, describing the
cellular composition of each.

77. Which area is called the thymus-independent area and why?

78. Briefly describe the specific roles of helper and cytotoxic T cells in
normal immunity.

79. Langerhans' cells are found in lymph nodes.

a) True

b) False

80. Macrophages have an impressive range of functions but appear unable to prime naive lymphocytes.

a) True

b) False

81. Lymphocytes in the lamina propria secrete large amounts of IgA.

a) True

b) False

82. CD8 is a marker for cytotoxic T-cells.

a) True

b) False

83. M cells present in the epithelial cell surface act as APC.

a) True

b) False

84. Memory cells are not produced during primary antigen encounter.

a) True

b) False

85. Bursa of Fabricius is the organ in birds where B cells maturate.

a) True

b) False

86. Dendritic cells are antigen presenting cells.

a) True

b) False

87. Specialized macrophages produce antibodies.

a) True

b) False

88. Neutrophils process and present antigen to B-cells.

a) True

b) False

89. Neutrophil is the major cell type of myeloid system.

a) True

b) False

90. Spleen is the primary lymphoid organ.

a) True

b) False

91. NK cells are capable of non-specific killing in virally transformed target cells and are involved in allograft and tumor rejection.

a) True

b) False

92. Bursa of Fabricius is site of Lymphocytic proliferation and differentiation.

a) True

b) False

93. Mast cells are white blood cells that migrate into the tissues and play an important role in development of allergies.

a) True

b) False

94. Lymphoid follicles are present only in spleen and lymphnodes.

a) True

b) False

95. The equivalent structure of Bursa in mammal is peyers patches.

a) True

b) False

96. Neutrophils are generally the first cells to arrive at the site of inflammation.

a) True

b) False

97. Basophil is a porymorphonuclear phagocytic cell.

a) True

b) False

98. M cells are present in thymus cortical region.

a) True

b) False

99. Thymocytes are immunologically competent cells.

a) True

b) False

100. Neutrophils are called martyrs of immune system.

a) True

b) False

101. Lymphocytes that have not interacted with antigen are referred to as naive cells.

a) True

b) False

102. A plasma cell can switch from IgM to IgG production and vice-versa.

a) True

b) False

103. Spleen in mammals is the equivalent organ for bursa in birds.

a) True

b) False

104. Macrophages are the accessory cells of the immune response.

a) True

b) False

105. Which area is called the thymus-independent area and why?

106. Null cells are not MHC-restricted. Explain. How do they kill their target
cells

107. What is the significance of follicles to antigen-induced B-cell differentiation?