Lesson 1 – Development in animal cytogenetics and animal immunogenetics of farm animals exam

1. The inoculation given to stimulate immunological memory response is
known as

a) Vaccination

b) Booster

c) Variolation

d) Inoculation

2. Edward Jenner invented the vaccine for small pox in

a) 1776

b) 1777

c) 1778

d) 1779

3. An antibody produced by a single clone of cells is known as

a) Monoclonal antibody

b) Auto antibody

c) Camelid antibodies

d) IgM

4. Fluorescent in-situ hybridization

a) Requires deoxynucleotides

b) Used in genetic mapping of genomes

c) Requires DNA polymerase

d Requires labeled probes

5. The term genome refers to the

a) Haploid set of chromosomes

b) Diploid set of chromosomes

c) Triploid set of chromosomes

d) Tetraploid set of chromosomes

6. During ploidy there is a change in the

a) Number of genes

b) Number of chromosomes

c) Arrangement of genes

d) Arrangement of chromosomes

7. Which of the following cytogenetic techniques would be the most likely
to identify a microdeletion?

a) G banding

b) R banding

c) Inversion analysis

) Fluorescence in situ hybridisation

8. The addition or deletion of one or more chromosomes in a set is referred
as

a) Deletion

b) Inversion

c) Aneuploidy

d) Translocation

9. Who discovered blood groups?

A) Thomas cooley

B) Camillo Golgi

C) Ernst Haecker

D) Karl Landsteiner

10. Lock and Key concept theory was proposed by

A) Kuhne

B) Koshland

C) Fischer

D) Arrhenius

11. Who proposed the clonal selection theory?

A) James Watson

B) Niles Jerne

C) Francis Crick

D) Frank MacFarlane Burnet

12. Who discovered the vaccination against smallpox?

A)Edward Jenner

B) Louis Pasteur

C) Barbara McClintock

D) Niles Jerne

13. Which of the following is used for typing when a patient is being
prepared for an organ transplant?

A)MHC class I molecules

B) MHC class II molecules

C) MHC class III molecules

D)All of the above

14. Cytogenetics

15. Karyology

16. Chromosome banding

17. Polyploidy

18. Robertsonian or centric fusions

19. Immunogenetics

20. Histocompatability genes

21. FISH

22. Multicolor FISH (mFISH)

23. Polyploidy is common among flowering plants

a)True

b)False

24. Side chain theory was proposed by Shibasabura Kitasato in 1890

a)True

b)False

25. Gerald Edelman and Rodney Porter independently published the
molecular structure of antibodies

a)True

b)False

26. Bovine leukocyte adhesion deficiency (BLAD) is a hereditary disease of
Jersey breed of cattle

a)True

b)False

27. Comparative Genomic Hybridisation (CGH) do require the preparation
of metaphase chromosomes from cells

a)True

b)False

28. Pinkel and his associates developed a method of fluorescent in situ
hybridisation (FISH) to visualise chromosomes using fluorescentlabelled probes

a)True

b)False

29. Robertsonian translocations are otherwise known as centric fusions

a)True

b)False

30. Spectral karyotyping and multicolor FISH are both advanced
molecular cytogenetic techniques for chromosome analysis

a)True

b)False

31. HLA genes are monomorphic, which means they have many different
alleles to fine-tune the adaptive immune system

a)True

b)False

1. Write in detail about the role of cytogenetics and immunogenetics for
genetic improvement of livestock